Last update
3/26/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.8
USERS' SCORE
Moderately Good
Based on 14 Reviews
7.6
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Proprietary Probiotic BlendLacticaseibacillus rhamnosus R0011Lactobacillus helvetius R0052Pediococcus acidilactici R1001Lacticaseibacillus casei R0215Bifidobacterium longum BB536Lactiplantibacillus plantarum R1012Bifidobacterium breve R0070Lactococcus lactis subsp. lactis R1058
131 mg (10 Billion CFU)
†
Top Medical Research Studies
9
In our investigation, we looked into whether Lactobacillus acidophilus can ease the symptoms of chronic fatigue syndrome (CFS). Rats were subjected to a swimming test to induce fatigue, which helped us measure their behavior.
We found that treatment with both free Lactobacillus and specially formulated beads reduced signs of fatigue and improved overall biochemical markers associated with CFS. This suggests that Lactobacillus could be a promising treatment option for CFS when delivered in the right way.
We found that treatment with both free Lactobacillus and specially formulated beads reduced signs of fatigue and improved overall biochemical markers associated with CFS. This suggests that Lactobacillus could be a promising treatment option for CFS when delivered in the right way.
Read More
7
In a pilot study with 39 patients suffering from chronic fatigue syndrome (CFS), we explored how Lactobacillus casei strain Shirota could impact emotional symptoms, particularly anxiety.
Over two months, participants were given either the probiotic or a placebo while providing stool samples and completing anxiety assessments.
Notably, we observed an increase in beneficial gut bacteria and a significant reduction in anxiety symptoms among those taking the probiotic, suggesting a potential link between gut health and emotional wellbeing.
Over two months, participants were given either the probiotic or a placebo while providing stool samples and completing anxiety assessments.
Notably, we observed an increase in beneficial gut bacteria and a significant reduction in anxiety symptoms among those taking the probiotic, suggesting a potential link between gut health and emotional wellbeing.
Read More
7
We explored the potential of probiotics in managing chronic fatigue syndrome (CFS) by reviewing randomized controlled trials. Our analysis included two high-quality studies on CFS patients that used Lactobacillus casei and Bifidobacterium infantis.
The results showed that Lactobacillus casei reduced anxiety levels, while Bifidobacterium infantis helped lower inflammation. Although these findings hint at positive effects, the overall evidence is still limited, and more research is required to establish the benefits of probiotics for CFS.
The results showed that Lactobacillus casei reduced anxiety levels, while Bifidobacterium infantis helped lower inflammation. Although these findings hint at positive effects, the overall evidence is still limited, and more research is required to establish the benefits of probiotics for CFS.
Read More
Most Useful Reviews
10
Immune system improvement
1 people found this helpful
This product works wonders for my chronic fatigue syndrome and has unexpectedly boosted my immune system, leaving me feeling less fatigued overall.
Read More
9
Immediate effect
1 people found this helpful
Suffering from chronic fatigue syndrome and frequent diarrhoea, this product had an immediate effect on my symptoms, helping to stabilise my bathroom habits.
Read More
7.5
Reduced discomfort
1 people found this helpful
After suffering from chronic fatigue syndrome and irritable bowel syndrome for years, I've found this product reduces my intestinal discomfort significantly. I'm grateful for its effects.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.8
- All Researches
9
In our investigation, we looked into whether Lactobacillus acidophilus can ease the symptoms of chronic fatigue syndrome (CFS). Rats were subjected to a swimming test to induce fatigue, which helped us measure their behavior.
We found that treatment with both free Lactobacillus and specially formulated beads reduced signs of fatigue and improved overall biochemical markers associated with CFS. This suggests that Lactobacillus could be a promising treatment option for CFS when delivered in the right way.
We found that treatment with both free Lactobacillus and specially formulated beads reduced signs of fatigue and improved overall biochemical markers associated with CFS. This suggests that Lactobacillus could be a promising treatment option for CFS when delivered in the right way.
Read More
7
We explored the potential of probiotics in managing chronic fatigue syndrome (CFS) by reviewing randomized controlled trials. Our analysis included two high-quality studies on CFS patients that used Lactobacillus casei and Bifidobacterium infantis.
The results showed that Lactobacillus casei reduced anxiety levels, while Bifidobacterium infantis helped lower inflammation. Although these findings hint at positive effects, the overall evidence is still limited, and more research is required to establish the benefits of probiotics for CFS.
The results showed that Lactobacillus casei reduced anxiety levels, while Bifidobacterium infantis helped lower inflammation. Although these findings hint at positive effects, the overall evidence is still limited, and more research is required to establish the benefits of probiotics for CFS.
Read More
7
We investigated whether treating gut microbiota imbalances could help improve sleep quality in people with Chronic Fatigue Syndrome (CFS). In a 22-day study involving 21 participants, we used antibiotics to target high levels of gram-positive faecal Streptococcus.
Those who responded well showed a notable increase in sleep duration compared to non-responders. While there was some improvement in mood and sleep for these individuals, overall, the treatment did not cause lasting changes in gut health for most participants.
Thus, while some outcomes were promising, more research is needed to fully explore how gut microorganisms might affect sleep and mood in CFS.
Those who responded well showed a notable increase in sleep duration compared to non-responders. While there was some improvement in mood and sleep for these individuals, overall, the treatment did not cause lasting changes in gut health for most participants.
Thus, while some outcomes were promising, more research is needed to fully explore how gut microorganisms might affect sleep and mood in CFS.
Read More
7
In a pilot study with 39 patients suffering from chronic fatigue syndrome (CFS), we explored how Lactobacillus casei strain Shirota could impact emotional symptoms, particularly anxiety.
Over two months, participants were given either the probiotic or a placebo while providing stool samples and completing anxiety assessments.
Notably, we observed an increase in beneficial gut bacteria and a significant reduction in anxiety symptoms among those taking the probiotic, suggesting a potential link between gut health and emotional wellbeing.
Over two months, participants were given either the probiotic or a placebo while providing stool samples and completing anxiety assessments.
Notably, we observed an increase in beneficial gut bacteria and a significant reduction in anxiety symptoms among those taking the probiotic, suggesting a potential link between gut health and emotional wellbeing.
Read More
4
We investigated the impact of specific probiotics, including Lactobacillus paracasei and Bifidobacterium lactis, on individuals with chronic fatigue syndrome (CFS). Fifteen patients participated in a structured study that included baseline observation, a probiotic regimen, and a follow-up. While we noted improvements in neurocognitive functions, the results revealed no significant changes in fatigue levels or physical activity. Interestingly, six out of fifteen patients reported subjective improvements in their health, suggesting that further exploration into probiotics for CFS treatment may be worthwhile.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 14 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
10
Immune system improvement
1 people found this helpful
This product works wonders for my chronic fatigue syndrome and has unexpectedly boosted my immune system, leaving me feeling less fatigued overall.
Read More
9
Immediate effect
1 people found this helpful
Suffering from chronic fatigue syndrome and frequent diarrhoea, this product had an immediate effect on my symptoms, helping to stabilise my bathroom habits.
Read More
7.5
Reduced discomfort
1 people found this helpful
After suffering from chronic fatigue syndrome and irritable bowel syndrome for years, I've found this product reduces my intestinal discomfort significantly. I'm grateful for its effects.
Read More
10
Resolved constipation
After suffering from chronic constipation for 27 years, I found relief! I had never been constipated until recently and was sceptical. The lactic acid bacteria had a quick effect. Following four months of a new routine, I finally started noticing changes. Taking two tablets each morning on an empty stomach was the winning formula for my chronic constipation. Jackpot!
Read More
10
Effective bacteria
This is the only lactic acid bacteria that has proven effective for managing my chronic fatigue syndrome. Highly recommended for anyone facing similar issues.
Read More
Frequently Asked Questions
7.5
Reduced fatigue
The effect of the lactobacillus is impressive! After taking two tablets daily on an empty stomach for about two weeks, I felt more comfortable and my fatigue diminished. This has been a valuable find for addressing my chronic fatigue syndrome.
10
Resolved constipation
After suffering from chronic constipation for 27 years, I found relief! I had never been constipated until recently and was sceptical. The lactic acid bacteria had a quick effect. Following four months of a new routine, I finally started noticing changes. Taking two tablets each morning on an empty stomach was the winning formula for my chronic constipation. Jackpot!
10
Immune system improvement
1 people found this helpful
This product works wonders for my chronic fatigue syndrome and has unexpectedly boosted my immune system, leaving me feeling less fatigued overall.
9
Immediate effect
1 people found this helpful
Suffering from chronic fatigue syndrome and frequent diarrhoea, this product had an immediate effect on my symptoms, helping to stabilise my bathroom habits.
0
Negative effects
1 people found this helpful
Unfortunately, this product did not work for me. I experienced severe stomach pain and distress after taking it, which negated any potential benefits for my chronic fatigue syndrome. I would not recommend it, especially for those with similar conditions.
2
No effect
I did not find this product effective in treating my chronic fatigue syndrome. Despite changing my routine, I struggled with severe constipation. It simply didn’t work for me.
7
We explored the potential of probiotics in managing chronic fatigue syndrome (CFS) by reviewing randomized controlled trials. Our analysis included two high-quality studies on CFS patients that used Lactobacillus casei and Bifidobacterium infantis.
The results showed that Lactobacillus casei reduced anxiety levels, while Bifidobacterium infantis helped lower inflammation. Although these findings hint at positive effects, the overall evidence is still limited, and more research is required to establish the benefits of probiotics for CFS.
The results showed that Lactobacillus casei reduced anxiety levels, while Bifidobacterium infantis helped lower inflammation. Although these findings hint at positive effects, the overall evidence is still limited, and more research is required to establish the benefits of probiotics for CFS.
7
In a pilot study with 39 patients suffering from chronic fatigue syndrome (CFS), we explored how Lactobacillus casei strain Shirota could impact emotional symptoms, particularly anxiety.
Over two months, participants were given either the probiotic or a placebo while providing stool samples and completing anxiety assessments.
Notably, we observed an increase in beneficial gut bacteria and a significant reduction in anxiety symptoms among those taking the probiotic, suggesting a potential link between gut health and emotional wellbeing.
Over two months, participants were given either the probiotic or a placebo while providing stool samples and completing anxiety assessments.
Notably, we observed an increase in beneficial gut bacteria and a significant reduction in anxiety symptoms among those taking the probiotic, suggesting a potential link between gut health and emotional wellbeing.
4
We investigated the impact of specific probiotics, including Lactobacillus paracasei and Bifidobacterium lactis, on individuals with chronic fatigue syndrome (CFS). Fifteen patients participated in a structured study that included baseline observation, a probiotic regimen, and a follow-up. While we noted improvements in neurocognitive functions, the results revealed no significant changes in fatigue levels or physical activity. Interestingly, six out of fifteen patients reported subjective improvements in their health, suggesting that further exploration into probiotics for CFS treatment may be worthwhile.
References
- Roman P, Carrillo-Trabalón F, Sánchez-Labraca N, Cañadas F, Estévez AF, et al. Are probiotic treatments useful on fibromyalgia syndrome or chronic fatigue syndrome patients? A systematic review. Benef Microbes. 2018;9:603. 10.3920/BM2017.0125
- Jackson ML, Butt H, Ball M, Lewis DP, Bruck D. Sleep quality and the treatment of intestinal microbiota imbalance in Chronic Fatigue Syndrome: A pilot study. Sleep Sci. 2015;8:124. 10.1016/j.slsci.2015.10.001
- Singh PK, Chopra K, Kuhad A, Kaur IP. Role of Lactobacillus acidophilus loaded floating beads in chronic fatigue syndrome: behavioral and biochemical evidences. Neurogastroenterol Motil. 2012;24:366. 10.1111/j.1365-2982.2011.01861.x
- Rao AV, Bested AC, Beaulne TM, Katzman MA, Iorio C, et al. A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome. Gut Pathog. 2009;1:6. 10.1186/1757-4749-1-6
- Sullivan A, Nord CE, Evengård B. Effect of supplement with lactic-acid producing bacteria on fatigue and physical activity in patients with chronic fatigue syndrome. Nutr J. 2009;8:4. 10.1186/1475-2891-8-4
Data last updated:
